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Academics

Teresa Seefeldt

Teresa Seefeldt

Title

Vice Provost for Undergraduate Education/Associate Professor

Office Building

Morrill Hall

Office

230

Mailing Address

Morrill Hall 230
Academic Affairs-Box 2201
University Station
Brookings, SD 57007

Education

  • B.S. in pharmaceutical sciences | South Dakota State University | 2002
  • Pharm.D. | South Dakota State University | 2004
  • Ph.D. in pharmaceutical sciences | South Dakota State University | 2007

Academic Interests

  • Pharmacology
  • Toxicology

Academic Responsibilities

  • VET 641 - Veterinary Pharmacology I
  • VET 664 - Veterinary Pharmacology II
  • HON 383 - Cancer: Individual and Societal Perspectives

Committees and Professional Memberships

  • American Pharmacists Association
  • American Association of Colleges of Pharmacy
  • American Chemical Society
  • American Heart Association
  • South Dakota Pharmacists Association

Awards and Honors

  • 2023, Hustead Award, South Dakota Pharmacists Association
  • 2021, 2020, 2006, Teacher of the Year, South Dakota State University College of Pharmacy.
  • 2021, Teacher of the Year, South Dakota State University Van D. and Barbara B. Fishback Honors College.
  • 2018, Excellence in Teaching Award, College of Pharmacy and Allied Health Professions.
  • 2016, Women of Distinction Award - Faculty Category, South Dakota State University.
  • 2014, Edward Patrick Hogan Award for Teaching Excellence.
  • 2014, Community Engagement Award, College of Pharmacy.
  • 2010-2011, American Association of Colleges of Pharmacy Academic Leadership Fellows Program.
  • 2007, Excellence in eLearning Award (Best Overall), South Dakota Board of Regents.

Areas of Research

  • Regulation of thiol redox state in cardiomyocytes
  • Development of models of thiol oxidative stress in cardiomyocytes

Publications

  1. Guan X, Dwivedi C, Kim SY, Fine T, Ratzsch A, Seefeldt T, Peitz G, Zhang Z. Mercapturic acid biosynthesis of 1-chloro-2,4-dinitrobenzene in rat kidney. Current Topics in Toxicology. 2004, 1, 153-160.
  2. Seefeldt T, Dwivedi C, Peitz G, Herman J, Carlson L, Zhang Z, Guan X. 2-Acetylamino-3- [4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)phenylcarbamoylsulfanyl]
    propionic acid and its derivatives as a novel class of glutathione reductase inhibitors. J Med Chem. 2005, 48, 5224-5231.
  3. Chen W, Zhao Y, Seefeldt T, Guan X. Determination of thiols and disulfides via HPLC quantification of 5-thio-2-nitrobenzoic acid. J Pharm Biomed Anal. 2008, 48, 1375-1380.
  4. Seefeldt T, Zhao Y, Chen W, Carlson L, Herman J, Stoebner A, Hanson S, Foll R, Guan X. Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione. J Biol Chem. 2009, 284, 2729-2737.
  5. Zhao Y, Seefeldt T, Chen W, Wang X, Matthees D, Hu Y, Guan X. Effects of glutathione reductase inhibition on cellular thiol redox and related systems. Arch Biochem Biophys. 2009, 485, 56-62.
  6. Zhao Y, Seefeldt T, Chen W, Carlson L, Stoebner A, Hanson S, Foll R, Matthees DP, Palakurthi S, Guan X. Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation. Free Radic Biol Med. 2009, 47, 176-183.
  7. Bennett L and Seefeldt T. The role of antioxidants on oxidative stress in diabetes mellitus. J Pharm Technol. 2010, 26, 293-299.
  8. Chen W, Seefeldt T, Young A, Zhang X, Guan X. Design, synthesis and biological evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl) cysteine (NACC) and its analogs as a novel class of anticancer agents. Bioorg Med Chem. 2011, 19, 287-294.
  9. Seefeldt T and Bennett L. The role of antioxidant vitamins in cardiovascular disease. J Pharm Technol. 2011, 27, 19-26.
  10. Bennett L, Rojas S, Seefeldt T. The role of antioxidants in the prevention of malignant disorders. Journal of Experimental and Clinical Medicine. 2012, 4, 215-222.
  11. Seefeldt T, Mort J, Brockevelt B, Giger J, Jordre B, Lawler M, Nilson W, Svien L. A pilot study of interprofessional case discussions for health professions students using the virtual world Second Life. Currents in Pharmacy Teaching and Learning. 2012, 4, 224-231.
  12. Chen W, Seefeldt T, Young A, Zhang X, Zhao Y, Ruffolo J, Kaushik RS, Guan X. Microtubule S-glutathionylation as a potential approach for antimitotic agents. BMC Cancer. 2012, 12, 245.
  13. Sadhu S, Callegari E, Zhao Y, Guan X, Seefeldt T. Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1. J Enzyme Inhib Med Chem. 2013, 28, 456-462.
  14. Xie J, Potter A, Xie W, Lynch C, Seefeldt T. Evaluation of a dithiocarbamate derivative as a model of thiol oxidative stress in H9c2 rat cardiomyocytes. Free Radic Biol Med. 2014, 70, 214-222.
  15. Mort J, Strain J, Helgeland D, Seefeldt T. Perceived impact of a longitudinal leadership program for all pharmacy students. Innovations in Pharmacy. 2014, 5(3), 1-11.
  16. Sadhu SS, Wang S, Averineni RK, Seefeldt T, Yang Y, Guan X.  In vitro and in vivo inhibition of melanoma growth and metastasis by the drug combination of celecoxib and dacarbazine.  Melanoma Res.  2016, 26(6), 572-579.
  17. Sadhu SS, Wang S, Averineni RK, Seefeldt T, Xie J, Tummala H, Guan X.  In vitro and in vivo anti-metastatic effect of glutathione disulfide liposomes.  Cancer Growth and Metastasis.  2017, 10, 1-11.
  18. Meyer BA, Seefeldt TM, Ngorsuraches S, Hendrickx LD, Lubeck PM, Farver DK, Heins JR.  Interprofessional education in pharmacology using high-fidelity simulation.  Currents in Pharmacy Teaching and Learning. 2017, 9, 1055-1062.
  19. Dachineni R, Kumar DR, Callegari E, Kesharwani S, Seefeldt T, Tummala H, Bhat GJ. Salicylic acid metabolites and derivatives inhibit CDK activity: a novel insight into aspirin's chemopreventive effects against colorectal cancer. Int J Oncol. 2017, 51, 1661-1673.
  20. Sankaranarayanan R, Valiveti CK, Kumar DR, Van Slambrouck S, Kesharwani S, Seefeldt T, Scaria J, Tummala H, Bhat GJ. The flavonoid metabolite 2,4,6-trihydroxybenzoid acid is a CDK inhibitor and an anti-proliferative agent: a potential role in cancer prevention. Cancers, 2019, 11(3), 427.
  21. Lee JW, Wang S, Huang Y, Seefeldt T, Donkor A, Logue BA, Woyengo TA. Toxicity of canola-derived glucosinolates in pigs fed resistant starch-based diets. J Anim Sci. 2020, 98(5), skaa111.
  22. Najmi A, Wang S, Huang Y, Seefeldt T, Alqahtani Y, Guan X. 2-(2-Cholesteroxyethoxyl)ethyl 3'-S-glutathionylpropionate and its self-assembled micelles for brain drug delivery: design, synthesis and evaluation. Int J Pharm. 2021, 600, 120520.
  23. Najmi A, Wang S, Huang Y, Seefeldt T, Alqahtani Y, Guan X. 2-(2-Cholesteroxyethoxyl)ethyl 3'-S-glutathionylpropionate (COXP) for brain-targeting liposomes. J Drug Deliv Sci Technol. 2022, 75, 103674.
  24. Lee JW, Wang S, Seefeldt T, Donkor A, Logue BA, Kim HS, Hong J, Woyengo TA. Porcine in vitro fermentation characteristics of canola co-products in neutral and acidic fermentation medium pH. Anim Feed Sci Technol. 2022, 284, 115188.

Department(s)